What is PRP?
PRP is a concentrated blood product that contains a high percentage of platelets (biomolecules with natural healing and regenerative properties).
Through activating platelets in PRP, cytokines in addition to growth factors (GFs) turn out to be bioactive and are released within 10 min right after clotting. These factors consist of vascular endothelial growth factor (VEGF), transforming growth factor, platelet-derived growth aspect, and epidermal growth factor. They can regulate cellular migration, attachment, proliferation plus differentiation, and promote extracellular matrix accumulation.
PRP therapy for ovarian rejuvenation :
PRP injected directly into the ovary releases cytokines and growth factors to heal and revive the local tissues in the ovaries to produce eggs again. In the case of women with premature ovarian insufficiency and menopause, it allows them to have a baby with their eggs.
The procedure is done in two steps:
- Around 20 ml of blood is withdrawn by vein puncture by ACP double syringe and it is processed for separation of PRP by the standard procedure of double centrifugation
- 2. The next step is the injection of the PRP into the ovaries in a procedure similar to egg pickup done during IVF. It is done under sedation / local anesthesia. The patient can go home in 1-2 hours.
As it is prepared from the patient’s own blood (autologous), hence it has no side effects.
PRP for uterine rejuvenation :
Endometrium thickness less than 7 mm is called thin endometrium and may be responsible for cycle failure. Currently, there are reports in the literature that infusion of PRP (Platelet Rich Plasma) in the uterus, helps in improving the thickness of the endometrium.
It has been quite successfully used in patients of RIF (recurrent implantation failure), where the PRP was done 48 hours before the embryo transfer.
The infertility workup starts with a detailed history of both partners followed by laboratory & imaging tests. For the female partner, these mainly focus on ovarian reserve, ovulatory function & evaluation of the uterus. For the male partner, the cornerstone of the infertility workup is the semen analysis. Any abnormalities in either of the partners are then evaluated accordingly.